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Somatic mutations in chromatin remodeler genes could modify the epigenomic landscape of CLL, but These are unusual in this malignancy as compared to other lymphoid neoplasms. CHD2 is mutated in 5% of CLL and seven% of MBL.75 The histone methyltransferase SETD2 and ARID1A are mutated in a small proportion of people. Of Be aware, MYD88 mutations and trisomy twelve are connected with unique remodeling of chromatin activation and accessibility areas.

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